Alexis Díaz, PhD

Díaz-García A, Yglesias-Rivera A, Ruiz-Fuentes JL, Ochoa-Cardentey R, Torres Viltres JR, Rodríguez-Sánchez H, Gómez Peña T. Effect of frequency of Rhopalurus junceus scorpion venom collection on protein content and biological activity. Trends Med; 19:1-5. doi: 10.15761/TiM.1000216.

Díaz-García A, Pimentel González G, Basaco Bernabeu T, Rodríguez Aurrecochea JC, Rodríguez Sánchez H, Sánchez Monzón I, Hernández Gómez M, Rodríguez Torres C, Regla Rodríguez Capote M, Guevara Orellanes I. Pharmacokinetics and Biodistribution of Rhopalurus junceus Scorpion Venom in Tumor-Bearing Mice ater Intravenous and Oral Administration. Iran Biomed J.23(4):287-296.

Díaz-García, A., Ruiz-Fuentes, J., Frión-Herrera, Y., Yglesias-Rivera, A., Riquenez Garlobo, Y., Rodríguez Sánchez, H., Rodríguez Aurrecochea, J., López Fuentes, L. Rhopalurus junceus scorpion venom induces antitumor efect in vitro and in vivo against a murine mammary adenocarcinoma model. Iranian Journal of Basic Medical Sciences; 22(7): 759-765. doi: 10.22038/ijbms.2019.33308.7956.

Frión-Herrera Y, Gabbia D, Díaz-García A, Cuesta-Rubio O, Carrara M. Chemosensitizing activity of Cuban propolis and nemorosone resistant human colon carcinoma cells. Fitoterapia; 136:104173.

Yglesias-Rivera Arianna, Díaz-García Alexis, Rodríguez-Sánchez Hermis. Synergistic effect of Rhopalurus junceus scorpion venom combined with conventional cytostatics in cervical cancer cell line HeLa. J Pharm Pharmacogn Res; 7(1): 67-76.

Yglesias-Rivera A, Díaz-García A. Effect of Rhopalurus junceus Scorpion Venom on Inflammation-Related Cytokines in Healthy BALB/C Mice. Ann Microbiol Immunol; 1(2):1007.

Díaz-Hung ML, Ruiz-Fuentes JL, Díaz-García A, León-Martínez R, Alberti-Amador E, Pavón-Fuentes N, Blanco-Lezcano L. Impairment in exploratory behavior is associated with arc gene overexpression in the dorsolateral striatum of rats with nigral injection of l-buthionine sulfoximine. Neurosci Lett; 687:26-30.

Valdés-Martínez Jany, Valdés-Hernández Iliana, Echemendía-Font Miguel, Rodríguez-Sánchez Hermis, Yglesias-Rivera Arianna, Díaz-García Alexis, Mycobacterium “habana” TMC 5135 as a vaccine candidate against tuberculosis: In vitro studies. Int J Mycobacteriol; 7(4):343-346.

Frión-Herrera Y, Díaz-García A, Ruiz-Fuentes J, Rodríguez- Sánchez H, Sforcin JM. The cytotoxic effects of propolis on breast cancer cells involve PI3K/Akt and ERK1/2 pathways, mitochondrial membrane potential, and reactive oxygen species generation Inflammopharmacology.; doi: 10.1007/s10787-018-0492-y.

Cos P, Janssens J, Piñón A, Cuesta-Rubio O, Yglesias-Rivera A, Díaz-García A, Vilegas W, Monzote L. Efficacy of Four Solanum spp. Extracts in an Animal Model of Cutaneous Leishmaniasis. Medicines (Basel).; 5(2). pii: E49.

Valdés-Hernández Iliana, Valdés-Martínez Jany, Rodríguez-Sánchez Hermis, Yglesias-Rivera Arianna, Díaz-García Alexis, Echemendía-Font Miguel. Diferencias en la fagocitosis de Mycobacterium "habana" TMC 5135 en cultivos celulares de macrófagos murinos. Vaccimonitor; 27( 1 ): 1-7.

Frión-Herrera Y, Díaz-García A, Ruiz-Fuentes J, Rodríguez-Sánchez H, Maurício Sforcin J. Mechanisms underlying the cytotoxic effect of propolis on human laryngeal epidermoid carcinoma cells. Nat Prod Res.; 8:1-7.

Alexis Díaz-García, Jenny Laura Ruiz-Fuentes, Hermis Rodríguez- Sánchez, José A Fraga Castro. Rhopalurus junceus scorpion venom induces apoptosis in the triple negative human breast cancer cell line MDA-MB-231. J Venom Res.; 8:9-13

Alexis Díaz-García, Jenny Laura Ruiz-Fuentes, Hermis Rodríguez- Sánchez, José A Fraga Castro. Rhopalurus junceus scorpion venom induces apoptosis in the triple negative human breast cancer cell line MDA-MB-231. J Venom Res.; 8:9-13

Hermis Rodríguez-Sánchez, Alexis Díaz-García, Yahima Frión-Herrera, Lianet Monzote Fidalgo Evaluación de la citotoxicidad de extractos marinos sobre un panel de líneas celulares. Rev Cub Farm; 50(1).

Marian Hernández-Colina, Alberto Martín Cermeño, Alexis Díaz García. Selective cytotoxic effect of 1-O-undecylglycerol in human melanoma cells. J Pharm Pharmacogn Res; 4(2):84-94.

Jenny Laura Ruiz-Fuentes, Alexis Diaz-Garcia, Odelaisy Suárez Moreno, Pedro Torres, Lucrecia Acosta. Evaluación de diferentes muestras para la detección molecular de Mycobacterium leprae en Cuba. Rev Cub Med Trop; 67(2).

JL Ruiz-Fuentes, A Díaz, A Entenza, Y Frión, O Suárez, P Torres, de Armas Y, L Acosta. Comparison of four DNA extraction methods for the detection of Mycobacterium leprae from Ziehl–Neelsen-stained microscopic slides. Int J Mycobacteriol; 4(4):284-289.

Alexis Díaz-García, Jenny Laura Ruiz-Fuentes, Arianna Yglesias-Rivera, Hermis Rodríguez-Sánchez, Yanelis Riquenes Garlobo, Osmel Fleitas Martinez, José A Fraga Castro. Enzymatic analysis of venom from Cuban scorpion Rhopalurus junceus. J Venom Res; 6:11-18.

Yahima Frión-Herrera, Alexis Díaz-García, Jenny Ruiz-Fuentes, Hermis Rodríguez-Sánchez, José Maurício Sforcin. Brazilian green propolis induced apoptosis in human lung cancer A549 cells through mitochondrial-mediated pathway. J Pharm Pharmacol. 67(10):1448-1456.

Yahima Frión-Herrera, Alexis Díaz-García, Hermis Rodríguez-Sánchez, Jenny L. Ruiz-Fuentes, Lianet Monzote Fidalgo and William N. Setzer. Cytotoxic effect of cuban propolis extracts on normal cells and in-vitro basal toxicity assay to estimate acute oral toxicity. Am J Essential Oils Nat Prod; 2(1):19-23.

Judith Mendiola, Erik L. Regalado, Alexis Díaz-García, Olivier P. Thomas, Aymé Fernández-Calienes, Hermis Rodríguez, Abilio Laguna & Olga Valdés.: In vitro antiplasmodial activity, cytotoxicity and chemical profiles of sponge species of Cuban coasts. Nat Prod Res.

Yahima Frión-Herrera, Alexis Díaz-García, Hermis Rodríguez-Sánchez, Jenny Ruiz-Fuentes, Lianet Monzote-Fidalgo, Luis Morier-Díaz, and William N. Setzer. Cytotoxic Effect of Cuban Propolis Extracts Against Tumor Cells Lines. Am J Essential Oils Nat Prod; 1(1): 112-117.

E Hernández, B González, A Díaz, M González, HJ Morris, L Delgado, CE Martínez. Ethnopharmacological evaluation of Trichilia hirta L. as anticancer source in traditional medicine of Santiago de Cuba. Bol Latinoam Caribe Plant Med Aromat; 12(2): 176–185.

Díaz G.A., Rodríguez S.H., Scull L.R. Citotoxicidad de extractos de plantas medicinales sobre la línea celular de carcinoma de pulmón humano A549. Rev Cub Farm 2011; 45 (1).

Sariego I., Monzote L., Scull R., Díaz A., Caballero Y. Activity of essential oils from Cuban plants against Leishmania donovani and Trichomonas vaginalis. Int J Essential Oil Ther; 2:1-3.

Yzquierdo S. S. L., Mederos C. L., Díaz G. A. Echemendia F. M. y Montoro C. E., 2007. Aplicación de RCP-PLFR en el diagnóstico de Micobacterias no tuberculosas. Rev Chil Infect; 24 (5):391-396.

P.R. Casanova, R. Cox, M. Rodriguez, A. Díaz Presentación liofilizada de antígeno de Toxoplasma gondii para estudios serológicos. Rev Bioingeniería y Fisica Médica Cubana; 6:25-30.

CONGRESS 80 ANNIVERSARY OF TROPICAL MEDICINE INSTITUE PEDRO KOURI, XI NATIONAL CONGRESS OF MICROBIOLOGY AND PARASITOLOGY, VI NATIONAL CONGRESO OF TROPICAL MEDICINE AND VI WORKSHOP OF HIV-AIDS (Cuba).

- BLOOD CIRCULATING CYTOKINES IN CUBAN PATIENTS INFECTED BY Helicobacter pylori. Onelkis Feliciano; Yglesias, Arianna; Diaz, Alexis; Gutierrez, Oderay; Llanes, Rafael. (POSTER).

- PHENOTIPIC Y GENOTIPIC CHARACTERIZATION OF TOXINOGENIC VIRULENCE FACTORS IN PSEUDOMONAS AERUGINOSA STRAINS ISOLATES FROM PATIENTS WITH QUISTIC FIBROSIS AND HIV-AIDS. Daniel Salazar; Ruíz, Jenny Laura; Díaz, Alexis; Aleaga, Yamilé; Espinosa, Taimí. (poster, coathor).

- DIFFERENCES IN PHAGOCITOSIS OF Mycobacterium ́habana ́ TMC 5135 ON PERITONEAL MACROPHAGES IN CELL CULTURE. Iliana del C. Valdés; Jany Valdés; Hermis Rodríguez; Arianna Yglesias; Alexis Díaz; Miguel Echemendía. (poster, coathor).

- IN VITRO EVALUATION OF Mycobacterium „habana TMC 5135 AGAINST TUBERCULOSIS. Jany Valdés; Valdés, Iliana; Echemendía, Miguel; Rodríguez, Hermis; Yglesias, Arianna; Díaz, Alexis. (poster, coathor)

- SCORPION VENOM AS NATURAL SOURCE FOR ANTIVIRAL DRUGS. Alexis Díaz García, Maritza Pupo-Antúnez. (conference).

CIASEM. Cuba. APOPTOSIS IN CERVICAL CANCER CELL HELA INDUCED BY RHOPALURUS JUNCEUS SCORPION VENOM INDUCES TROUGH MITOCHONDRIAL PATHWAY. Alexis Díaz-García, Jenny Laura Ruiz-Fuentes, Hermis Rodríguez-Sánchez. (conference).

ECFA 2017. Cuba. EVALUACIÓN DEL EFECTO ANTIPROLIFERATIVO DE LA COMBINACIÓN DEL VENENO DEL ESCORPIÓN R. JUNCEUS CON CITOSTÁTICOS CONVENCIONALES. Arianna Yglesias Rivera, Alexis Díaz García, Hermis Rodríguez Sánchez. (poster, coauthor).

IXth Academician NICOLAE CAJAL Symposium & FEAM Spring Conference, Rumania. "Potentiality of RjLB-14 for cancer treatment" (conference).

IXth Academician NICOLAE CAJAL Symposium & FEAM Spring Conference, Rumania. "Potentiality of RjLB-14 for cancer treatment" (conference).

III International Congress Health science CICS-UDABOL, Bolivia. "Potentialities of RjLB-14 peptide for anticancer treatment." (conference).

LATINFARMA. RjLB-14 PEPTIDE: EXPERIMENTAL EVIDENCES AND POTENTIAL IN CANCER TREATMENT Cuba. (conference).

Workshop of Toxins application in Biomedicine: Development toxin-based products Cuba. Rhopalurus junceus scorpion venom: Natural source of antitumor natural peptides. (conference).

5th International Workshop of Chemistry Cuba. Cytotoxic effect of Cuban propolis extract against tumor cells lines (poster, coauthor).

ACADEMICIAN NICOLAE CAJAL SYMPOSIUM, Rumania. Venom from the scorpion Rhopalurus junceus, a potential alternative for anticancer therapy. (Conference).

IX Congress Sea Science: MarCuba Cuba. Antiplasmodial and Antitumoral activities of sponge species from Cuban coast. (coauthor).

II International Congress LABIOFAM II Workshop of natural products for anticancer therapy. Havana, Cuba. Natural compounds from cuban sponges with bioactivities in in vitro e in vivo murine models of malaria and Hela cancer cell line (Poster, coauthor).

II International Congress LABIOFAM II Workshop of natural products for anticancer therapy. Havana, Cuba. Citotoxic effect from cuban propolis against cancer cell lines. (Poster, coautor).

II International Congress LABIOFAM II Workshop of natural products for anticancer therapy. Havana, Cuba. Stability of natural extract from cuban scorpion venom Rhopalurus junceus. (Poster, coauthor).

II International Congress LABIOFAM II Workshop of natural products for anticancer therapy. Havana, Cuba. In vitro effect against cancer cell lines of different homeopathic formulations from scorpion venom Rhopalurus junceus. (conference).

II International Congress LABIOFAM II Workshop of natural products for anticancer therapy. Havana, Cuba. Venom from cuban scorpion Rhopalurus junceus: coctel of antitumoral natural peptides. (conference).

3rd International workshop of pharmacology of natural products. FAPRONATURA . Cuba. Potentiality of use of scorpion Rophalurus junceus venom in the treatment of cancer. (conference).

XI Congress of Pharmaceutical Science. CUBAFARMACIA. Havana, Cuba. VIDATOX: An alternative for anticancer treatment. (conference).

EVENTO NOVEDADES MÉDICAS. CIMEQ Habana 2012 Cuba. Uso de péptidos antitumorales en el complemento de la terapia del cáncer. (conference).

I Jornada Provincial Farmacéutica. II Taller Provincial Farmacia Hospitalaria. Holguín, Cuba. (conference).

VII International Congress of Veterinary Science. Havana, Cuba. Rhopalurus junceus cuban venom: from empirical knowledge to science. (conference).

SCIENTIFIC MEETING LABIOFAM-BIOVIETNAM. Hanoi, Viet Nam. Genomic and Proteomic identification of components of venom from Cuban scorpion Rhopalurus junceus. (coauthor).

SCIENTIFIC MEETING LABIOFAM-BIOVIETNAM. Hanoi, Viet Nam. Rhopalurus junceus cuban venom: from empirical knowledge to science. (conference).

4th International Congress of Pharmacology and Therapy. Havana Pharmacology, Cuba. 2nd Workshop of natural products pharmacology. Rhopalurus junceus cuban venom: from empirical knowledge to science./Veneno del escorpión cubano Rhopalurus junceus: del conocimiento empírico a la ciencia (conference).

I International Congress LABIOFAM . 1st Workshop of natural products for anticancer therapy. Cuba. Rhopalurus junceus cuban venom: from empirical knowledge to science (conference).

II National Workshop of scorpion venom. I International Workshop of Toxinology. I International meeting of Clinical treatment. Guantánamo. Cuba. “Characterization and comparison of Rhopalurus junceus y Centruroides gracilis scorpion venoms belonging to Buthidae Family.” (conference).

VI Congreso Nacional de Bioingeniería y Física Médica. Havana Cuba. “Nueva presentación de antígeno de Toxoplasma gondii para estudios serológicos" (Poster, coauthor).

Biotechnology 2003. Havana, Cuba. Use of PRA for rapid identification of Mycobacterias in clinic laboratories. (Poster, coauthor).

Biotechnology 2003. Cuba. Partial Biochemical characterization and evaluation of biological activity of Rhopalurus junceus scorpion venom in three cancer cell lines and lung normal fibroblast (Poster, coauthor).